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Is it possible/wise to share PSDZ data folders between ESYS and ISTA P?

Only reason is having two sets of the files feels like I'm wasting 50GB+ of hard drive.

Don't know if it is wise, but it is possible if you work with Symlinks.

For creating a symlink
1. Delete Folder which should contain additional PSDZdata
1. Start CMD with elevated Adminrights.
2. execute 'mklink /D C:\PATHtoSYMLINK C:\PathtoPSDZdataFolder'

That is just an example. Of course you have different folders you have to copy. So you should also link every needed folder