[koziol]

2011 BMW 550i ,F-10 came to the shop ,car was in lime home mode
 scanned with Ista over 50 errors ,missing DSC  module and some FlexRay controller signaling fault. 
 checked the fuses ,fuse F2 5A  blown ,
replaced blown fuse and all faults were gone .
Drove the car for 15 min everything was fine ,scanned it again to make sure all is fine only one fault code 
1C3204  Engine oil pressure switch ,open circuit or switch sticking,
I parked the car on side.Car was parked nobody was touching it.
Around 2Hr later  I heard the sound same as when you open a door,than i turned the ignition on and all light were on again and same errors, F2 fuse blown .
what can cause this fuse to blown ?
Vin:C785210

[RocketSurgeon]

Fuse F2 powers the DSC module, all 4 comfort access door handles, and the comfort access trunk.
It's not uncommon to have a comfort access handle short out. I would look into the comfort access handles

[inspi1981]

Exactly, there should be also some faults related to CA handles

[carat10_2]

handles is dead, very often burn handles and create large smoke, try smell handles

[koziol]

yes right front passenger side handle smell
even when this fuse is blown CA work on all doors and trunk except that smelly one.

[RocketSurgeon]

You may already know this, but ISTA+ will tell you what draws power through a specific fuse. I discovered this while troubleshooting an hpfp. If you do a text search for "Fuse F2," and locate the SSP document bearing that name, it will pull up a diagram showing exactly what is on that circuit.
Smelling the handles is a great idea, I didn't realize you could isolate the problem like that!